In Port Royale 3, players will embark upon an epic adventure through the Caribbean during the turbulent 17th century where the naval powers of Spain, England, France and the Netherlands all fight for supremacy in the colonies. Players take on the role of a young captain trying to build his fortune and reputation in the new world colonies. The campaign consists of two different paths for the young protagonist to follow: adventurer and trader.

Following the path of the adventurer will lead the player on a naval conquest where they must gain notoriety through raids, piracy, bounty hunting, plundering and conquering cities as they strive to build their new Caribbean empire.