Naïve T cell express the highest molecular weight isoform of CD45, CD45 RA. Those express CD4 and are negative for CD25 are destined to become T helper cells. Naïve T cells differentiated in bone marrow, successfully undergone the positive and negative processes of central selection in the thymus, and have not yet been exposed to antigens. 

Our Human Peripheral Blood CD4+/CD45RA+ Naive T cells are isolated from peripheral blood mononuclear cells by negative immunomagnetic selection. All peripheral blood is collected in acid-citrate-dextrose formula A (ACDA) by leukapheresis from fully consented IRB approved donors that are tested negative for HIV, HBV and HCV.

Our Product was utilized in:

• Hopkins, Brooks, et al. "An In-Vitro Study of the Expansion and Transcriptomics of CD4+ and CD8+ Naïve and Memory T Cells Stimulated by IL-2, IL-7 and IL-15." Cells 11.10 (2022): 1701.  https://doi.org/10.3390/cells11101701