Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a myeloproliferative disease with an incidence of 1-2 cases per 100,000 adults. On the molecular level, CML is caused by the formation of Philadelphia chromosome, a genetic translocation t(9;22)(q34;q11.2) which creates a fusion oncogene of BCR-ABL. The expression of Tyrosine kinase BCR-ABL1 in hematopoietic stem/progenitor cells transforms them into leukemic cells, leading to increased and unregulated growth in the bone marrow and the accumulation of these cells in the blood.

HumanCells can obtain diseased samples when they become available to our network of clinicians. Some disease types may have a long backorder depending on the frequency of the disease occurrence in the general population. All samples come from fully consented IRB approved collections.