• IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.
• In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients
• Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro
• Silymarin can down-regulate gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)
• Curcumin inhibits human breast cancer cell growth by mediating certain signalling cascades including the modulation of the NF-κB signalling pathway
• Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression
• Suitable for vegetarians/vegans

Description

In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative. As such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women. Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events. Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5 It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.

Medicinal Ingredients
Each Vegetarian Capsule Contains:

• Calcium D-Glucarate (d-Glucaric Acid Calcium Salt) 75 mg
• Indole-3-Carbinol (3-Hydroxymethylindole) 75 mg
• Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine) 50 mg
• Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene) 50 mg
• Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane) 27.5 mg
• DIM (3,3’-Diindolylmethane) 25 mg
• Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids) 25 mg
• Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin) 25 mg
• Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf) 12.5 mg

* Epigallocatechin-3-gallate

Non-Medicinal Ingredients
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.

Allergens:
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Recommended Use:
3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.