Clinical Applications:

• Provides Intracellular Antioxidant Support*
• Supports Healthy Cell Function and Healthy Aging*
• Supports Detoxification*
• Supports a Healthy Immune Response*
• Supports Amino Acid Transport Across Cell Membranes*
• Enhances Antioxidant Activity of Vitamins C and E*
Clinical Applications

Perfect Activated Glutathione is an acetylated form of glutathione. This form is well-absorbed and more
stable throughout the digestive tract than other forms on the market. Use of stomach acid-resistant capsules
(DRcapsTM) further protect stability. Laboratory data showed that Perfect Activated Glutathione increased
intracellular glutathione and had a positive effect on many oxidative stress biomarkers.*

Discussion
Reduced glutathione, commonly known as glutathione or GSH, is a tripeptide consisting of L-glutamine, L-cysteine, and
glycine. It is ubiquitous in living systems. Glutathione biosynthesis can be affected by biochemical individuality and/or dietary
factors. Chronic oxidative stress can also deplete cellular glutathione. Precursors to glutathione, such as whey protein,
vitamin C, and glutamine, are often recommended to boost glutathione levels in the body; however, results are inconsistent.
Biological individuality is such that not every body has equivalent ability to metabolize the precursor to raise glutathione.*
Why Not Give Pure Glutathione? Unfortunately, most oral forms of glutathione are foul smelling, but more importantly,
the majority of an oral dose is oxidized before it can be absorbed and used by the cells. This formulation delivers a unique
preparation of glutathione that overcomes these usual limitations. The stability of S-acetylglutathione through the intestinal
wall and the plasma is well documented in the literature. Oral intake of S-acetylglutathione increases total glutathione and
percent-reduced glutathione. Percent-reduced glutathione is a very significant biomarker of health status.*[1-5]
Mechanism of Absorption S-acetylglutathione, a lipid-like compound, is taken up intact by chylomicrons in the gut. The
acetyl bond is placed on its thiol group or sulfur group, which prevents oxidation and allows the molecule to pass diffusively
into the cell after absorption in the gut. The bond is then cleaved by non-specific enzymes inside the cell. Acetylation
prevents the breakdown of glutathione, and S-acetylglutathione does not require energy expenditure to be cleaved to
reduced glutathione once it crosses the cell wall.*[1-8]
Antioxidant Activity Glutathione functions extensively in tissues and organs throughout the body. It plays critical roles in
protecting the body from oxidative stress, maintaining cellular functions, and supporting healthy immune function.[1,4] Many
factors can increase cellular exposure to oxidative insult, and therefore increase cellular consumption of nutrients—such
as glutathione—that provide antioxidant activity. This may result in a fierce cycle of oxidative stress and challenges to
detoxification. Complete biotransformation and protection from oxidative stress are important to maintaining cellular integrity
and tissue health.*[2,5]
Other Benefits of Maintaining Healthy Glutathione Levels Much information related to mitochondrial health has surfaced
in the literature. Mitochondria, the energy-producing powerhouses of cells, are also the primary intracellular site of oxygen
consumption and the major source of reactive oxygen species (ROS). S-acetylglutathione has been shown to cross the
membrane of the mitochondria, increasing the organelle’s activity and minimizing ROS.

.[8,9] Reduction of ROS is associated
with maintaining mitochondrial integrity and function, and improved mitochondrial health is believed to support overall health
and energy.*
S-acetylglutathione has also been shown to decrease TNF-alpha, NF-kappa beta, and F-2 isoprostane.[4,9-12] Additionally,
there is mounting evidence that intracellular glutathione levels in antigen-presenting cells (e.g. macrophages) may influence
the Th1/Th2 cytokine response pattern and promote a balanced immune reaction.*[10]

Directions
Take one to two capsules one to two times daily, or as
directed by your healthcare professional.
Consult your healthcare professional prior to use.
Individuals taking medication should discuss potential
interactions with their healthcare professional. Do not use
if tamper seal is damaged.