In Imperium Maledictum, players take on the roles of Imperial citizens and adepts who are recruited by a powerful and influential Patron. These teams operate outside the usual chain of command to undertake grim missions and further their Patron's often secret agendas. To succeed, players must navigate a web of competing factions, where a whispered accusation can be as deadly as a bolter.

• System: The game uses a refined d100 system, which is similar to the system used in previous Warhammer 40,000 RPGs like Dark Heresy.
• Gameplay Focus: The primary focus is on investigation and social encounters, rather than high-octane combat. Combat is deadly, and the unique "Superiority" system rewards careful preparation.
• Character Creation: The core rulebook provides six character roles influenced by a character's homeworld and faction, each with unique talents and equipment.