Natural Factors SAMe provides a direct source of S-adenosyl-L-methionine, a naturally occurring compound found in every cell in the body. SAMe helps support healthy mood balance through the synthesis of serotonin, dopamine, and phosphatidylserine, important mood-balancing compounds. It also helps relieve joint pain caused by osteoarthritis and contributes to numerous metabolic processes. This dual-action formula comes in easy-to-swallow, enteric-coated tablets that enhance its absorption and stability.