SNIPER(ABL)-050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein.

Product information

Molecular Weight: 1213.47

Formula: C68H84N12O9

Chemical Name: 4-[(4-{2-[2-(2-{2-[(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3, 3-diphenylpropanamido]ethoxy}ethoxy)ethoxy]acetyl}piperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide

Smiles: CC1=CC=C(C=C1NC1=NC(=CC=N1)C1=CN=CC=C1)NC(=O)C1C=CC(CN2CCN(CC2)C(=O)COCCOCCOCCNC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C2CCCCC2)C(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1

InChiKey: PBMLWDMSBSZGHC-KOMGJWJNSA-N

InChi: InChI=1S/C68H84N12O9/c1-47-23-28-55(43-57(47)75-68-72-31-29-56(74-68)54-21-13-30-70-44-54)73-64(83)53-26-24-49(25-27-53)45-78-34-36-79(37-35-78)59(81)46-89-42-41-88-40-39-87-38-32-71-66(85)62(60(50-15-7-4-8-16-50)51-17-9-5-10-18-51)77-65(84)58-22-14-33-80(58)67(86)61(52-19-11-6-12-20-52)76-63(82)48(2)69-3/h4-5,7-10,13,15-18,21,23-31,43-44,48,52,58,60-62,69H,6,11-12,14,19-20,22,32-42,45-46H2,1-3H3,(H,71,85)(H,73,83)(H,76,82)(H,77,84)(H,72,74,75)/t48-,58-,61-,62-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Products are for research use only. Not for human use.